Activation of long‐chain free fatty acid receptor FFAR1 (GPR40) and FFAR4 (GPR120) causes release of brain‐derived neurotropic factor from enteric glial cells (905.2)
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چکیده
منابع مشابه
Cloning, Identification and Functional Characterization of Bovine Free Fatty Acid Receptor-1 (FFAR1/GPR40) in Neutrophils
Long chain fatty acids (LCFAs), which are ligands for the G-protein coupled receptor FFAR1 (GPR40), are increased in cow plasma after parturition, a period in which they are highly susceptible to infectious diseases. This study identified and analyzed the functional role of the FFAR1 receptor in bovine neutrophils, the first line of host defense against infectious agents. We cloned the putative...
متن کاملFlow cytometry-based binding assay for GPR40 (FFAR1; free fatty acid receptor 1).
GPR40 is a G protein-coupled receptor (GPCR) whose endogenous ligands have recently been identified as medium- and long-chain free fatty acids (FFAs), and it is thought to play an important role in insulin release. Despite recent research efforts, much still remains unclear in our understanding of its pharmacology, mainly because the receptor-ligand interaction has not been analyzed directly. T...
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Objective: It was previously reported that increasing serum level of glucagon-like peptide-2 (GLP-2) is a risk factor of migraine in human. The headache phase of a migraine attack is thought to originate in vasodilation of meningeal blood vessels followed by activation of the nociceptive trigeminal nerve innervating these vessels. However, it is unclear how GLP-2 acts on this pathway. In the pr...
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Psychotherapy and pharmacotherapy have been the mainstays for the treatment of depression and anxiety disorders during the last century. However, treatment response has not improved in the last few decades. For instance, only half of all patients respond to mainstay antidepressants. To fulfill the needs of the remaining patients, there is a need to find treatments with better efficacy. The addi...
متن کاملFree fatty acid release from endothelial cells.
Cultured bovine aortic endothelial cells that have been previously enriched with fatty acid are able to release free fatty acid (FFA) into the extracellular fluid. No stimulus other than the presence of albumin in the medium is needed to elicit the FFA release. Intracellular triglycerides appear to be the source of most of the FFA that is released. The released FFA is composed of a mixture of f...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2014
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.28.1_supplement.905.2